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KMID : 0984920080100010026
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Journal of Skin Barrier Research
2008 Volume.10 No. 1 p.26 ~ p.33
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Retinyl retinoate as cosmetic anti-aging ingredients:new hybrid retinoid derivatives
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Kim Hyo-Jung
Um Soo-jong
Ahn Sung-Ku
Kim Nam-Soo
Kang Seung-Joo
Kim Bo-Ra
Kim Jin-Eun
Lee Gae-Jong
Kim Hyuk
Lee Joo-Dong
Ryoo Hee-Chang
Jung Hyung-Il
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Abstract
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Retinoids (vitamin A and vitamin A derivatives), such as retinol (ROL) and retinoic acid (RA), have received a great deal of attention by the cosmetics industry for their use as anti-wrinkle agents. However, neither RA nor ROL are widely used due to skin irritation and poor photostability, respectively. For this reason, safety and photo-stability have been important issues for the continued development of RA or ROL derivatives. To improve the photo-stability of retinol, a new hybrid, retinyl retinoate, was synthesized with a condensing reaction to form an ester bond between ROL (which has a hydroxyl end group) and RA (which has a carboxyl end group); the biological activity of the hybrid was also analyzed. Retinyl retinoate, a novel hybrid derivative, has better chemical stability, reduced skin irritant properties, and higher skin
regeneration activity than either ROL or RA alone, and is thus a promising anti-wrinkle agent.
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KEYWORD
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photo-aging, wrinkle, retinoid, retinol, vitamins
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